Verhaagen Groep
Neurodegeneratieve ziektes, dwarslaesie, neuroregeneratie, gentherapie
Over de Verhaagen Groep
Wereldwijd hebben vier miljoen mensen een dwarslaesie: een forse beschadiging van het ruggenmerg waardoor de hersenen er niet meer in slagen de spieren aan te sturen. Een dwarslaesie ontstaat vaak door een ongeval, maar bijvoorbeeld ook doordat een armpje van een ongeboren baby tijdens de bevalling klem zat in het geboortekanaal. Een chirurg kan deze mensen opereren, maar dit leidt vaak maar tot gedeeltelijk herstel. Een nieuwe gentherapie kan op termijn waarschijnlijk wel een oplossing bieden.
Het laboratorium voor Neuro-regeneratie onderzoekt zenuwweefselschade en -herstel. Bij een dwarslaesie kunnen de hersenen geen boodschappen meer sturen naar de spieren, omdat de zenuwvezels tegengehouden worden door het littekenweefsel dat in het ruggenmerg is ontstaan. Wij willen dit littekenweefsel doordringbaar maken voor zenuwvezels, zodat ze erdoorheen kunnen groeien naar de spieren aan de “overkant”. Dan kunnen de hersenen weer met spieren communiceren.
Meer weten over dit onderzoek en gentherapie? Luister dan deze aflevering van de Master the Mind podcast.
Joost Verhaagen:
Wat is het probleem dat u moet tackelen?
‘We zoeken naar manieren om het herstel van zenuwcellen te bevorderen na zenuwletsel. Daarvoor is het nodig dat we de mechanismen die het herstel belemmeren begrijpen en een manier vinden om de moleculen die het herstel stimuleren, af te leveren bij de beschadigde zenuwcellen’.
Hoe heeft u dat aangepakt?
‘Zenuwcellen in de hersenen en in het ruggenmerg slagen er niet in om de juiste stappen te activeren die nodig zijn voor het herstel van de beschadigde zenuwvezels. Zenuwcellen die buiten het centrale zenuwstelsel liggen herstellen wél, omdat zij beschikken over moleculen die het herstel met kracht aanzwengelen. Wij weten welke genen hiervoor verantwoordelijk zijn en kunnen deze ook gebruiken. We leveren ze af bij de beschadigde zenuwcellen door middel van gentherapie. Dit is een efficiënte en zeer nauwkeurige methode om een neuroactief en potentieel therapeutisch gen in te zetten met als doel herstel te bevorderen’.
‘Een andere reden waarom het herstel niet lukt, is omdat remmende eiwitten rondom beschadigde zenuwvezels het herstel belemmeren. We zijn erachter gekomen dat een eiwit genaamd Semaphorine3A, dat zenuwvezels afremt in hun groei, wordt aangemaakt in beschadigd ruggenmergweefsel.’
‘Onlangs hebben we ontdekt dat Semaphorine3A ook onderdeel is van zogenaamde perineuronale netten’, legt Verhaagen uit. ‘Dit zijn netachtige-structuren rondom de zenuwcellen. Ze stabiliseren de contacten tussen zenuwcellen en vervullen een sleutelrol bij herstelprocessen in de hersenen en bij leren en geheugen. Veranderingen in deze structuren zijn ook van invloed op het verloop van neurologische en psychiatrische aandoeningen, zoals de ziekte van Alzheimer’.
Hoe ziet u de toekomst?
‘Ik verwacht dat gentherapie met groeibevorderende genen en gentherapie met als doel de net-structuren te veranderen een belangrijke aanpak wordt om herstel en hersenplasticiteit te bevorderen. In de toekomst kan het zijn dat onderzoek naar perineuronale netten tijdens normale processen, zoals bijvoorbeeld leren en geheugen, en bij hersenaandoeningen, kan zorgen voor onverwachte behandelingen voor hersenziekten.’
Publicaties
Production of High-Yield Adeno Associated Vector Batches Using HEK293 Suspension Cells
Gene-expression profiling of individuals resilient to Alzheimer’s disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response
The concept of resilience to Alzheimer’s Disease
Vision on gyrate atrophy
Gene therapy and peripheral nerve repair
#3 Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells
Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells
Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury
Characterization of an immune-evading doxycycline-inducible lentiviral vector for gene therapy in the spinal cord
Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline
Molecular Changes in the Dorsal Root Ganglion during the Late Phase of Peripheral Nerve Injury-induced Pain in Rodents
The Jun-dependent axon regeneration gene program
Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
The Effect of Inflammatory Priming on the Therapeutic Potential of Mesenchymal Stromal Cells for Spinal Cord Repair
Semaphorins in Adult Nervous System Plasticity and Disease
Coordinated changes in the expression of Wnt pathway genes following human and rat peripheral nerve injury
An Extracellular Perspective on CNS Maturation
CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease
Macrophage-Derived Inflammation Induces a Transcriptome Makeover in Mesenchymal Stromal Cells Enhancing Their Potential for Tissue Repair
GDNF Gene Therapy to Repair the Injured Peripheral Nerve
Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries
Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract
Combining timed GDNF and ChABC gene therapy to promote long-distance regeneration following ventral root avulsion and repair
Regeneration of adult rat sensory and motor neuron axons through chimeric peroneal nerve grafts containing donor Schwann cells engineered to express different neurotrophic factors
ORANGE
Cerebellar plasticity and associative memories are controlled by perineuronal nets
The Effects of Sindbis Viral Vectors on Neuronal Function
Recent advances in the therapeutic uses of chondroitinase ABC
Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion
Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis
Inhibition of Semaphorin3A Promotes Ocular Dominance Plasticity in the Adult Rat Visual Cortex
Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.
Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer’s disease
Intrinsic Determinants of Axon Regeneration
Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury.
Mesenchymal Stem Cell-Macrophage Choreography Supporting Spinal Cord Repair
The dorsal column lesion model of spinal cord injury and its use in deciphering the neuron-intrinsic injury response
Integrins promote axonal regeneration after injury of the nervous system
Functional and neurophysiological evidence of the efficacy of trophic pharmacotherapy using an adrenocorticotrophic hormone4-9 analog in experimental allergic encephalomyelitis, an animal model of multiple sclerosis
Upregulation of B50/GAP-43 protein mRNA in rat dorsal root ganglia during cisplatin intoxication
Directed expression of the growth-associated protein B-50/GAP-43 to olfactory neurons in transgenic mice results in changes in axon morphology and extraglomerular fiber growth
Continuous renewal of the axonal pathway sensor apparatus by insertion of new sensor molecules into the growth cone membrane
Efficient adenoviral vector-directed expression of a foreign gene to neurons and sustentacular cells in the mouse olfactory neuroepithelium
Transient gene transfer to neurons and glia
Adenoviral vector-mediated gene transfer and neurotransplantation
Anatomy of rat semaphorin III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis
Longitudinal in vivo magnetic resonance imaging studies in experimental allergic encephalomyelitis
Long-term transgene expression in fetal rat suprachiasmatic nucleus neurografts following ex vivo adenoviral vector-mediated gene transfer
Adenoviral vector-mediated gene expression in the nervous system of immunocompetent Wistar and T cell-deficient nude rats
Adenoviral vector-directed expression of neurotrophin-3 in rat dorsal root ganglion explants results in a robust neurite outgrowth response
Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo
Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting after axotomy but not axon regeneration into growth-permissive transplants
B-50, the growth associated protein-43
Transgene expression in rat fetal brain grafts is maintained for 7 months after ex vivo adenoviral vector-mediated gene transfer
Anatomical distribution of the chemorepellent semaphorin III/collapsin-1 in the adult rat and human brain
Manipulation of gene expression in the mammalian nervous system
Adenoviral vector-mediated gene delivery to injured rat peripheral nerve
Viral vectors, tools for gene transfer in the nervous system
Growth of pyramidal, but not non-pyramidal, dendrites in long-term organotypic explants of neonatal rat neocortex chronically exposed to neurotrophin-3
Regulation of semaphorin III/collapsin-1 gene expression during peripheral nerve regeneration
Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in the facial nucleus of the rat
NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats
Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons
Neurotrophic ACTH4-9 analogue therapy normalizes electroencephalographic alterations in chronic experimental allergic encephalomyelitis
Semaphorin III
Role for semaphorin III and its receptor neuropilin-1 in neuronal regeneration and scar formation?
The role of the neural growth associated protein B-50/GAP-43 in morphogenesis
Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS
Ontogeny of neurotrophin receptor trkC expression in the rat forebrain and anterior hypothalamus with emphasis on the suprachiasmatic nucleus
Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system
Semaphorins and their receptors in olfactory axon guidance
Adenoviral vector-mediated expression of a foreign gene in peripheral nerve tissue bridges implanted in the injured peripheral and central nervous system
Transgenic expression of B-50/GAP-43 in mature olfactory neurons triggers downregulation of native B-50/GAP-43 expression in immature olfactory neurons
The use of adenoviral vectors and ex vivo transduced neurotransplants
Comparison of neurotrophin and repellent sensitivities of early embryonic geniculate and trigeminal axons
Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function
Tropism of AAV-2 vectors for neurons of the globus pallidus
Ectopic adenoviral vector-directed expression of Sema3A in organotypic spinal cord explants inhibits growth of primary sensory afferents
Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin3A
Emerging roles for semaphorins in neural regeneration
Adenoviral vector-mediated expression of neurotrophin-3 increases neuronal survival in suprachiasmatic nucleus grafts
Mutant ubiquitin expressed in Alzheimer’s disease causes neuronal death
Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord
Injury-induced class 3 semaphorin expression in the rat spinal cord
Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats
Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord
Adeno-associated viral vectors as agents for gene delivery
Semaphorins
Pharmacological, cell, and gene therapy strategies to promote spinal cord regeneration
Neuropilin and class 3 semaphorins in nervous system regeneration
Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function
Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting
Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway
Role of semaphorins in the adult nervous system
Meningeal cell-derived semaphorin 3A inhibits neurite outgrowth
The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways
Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord
Sema3A regulates the timing of target contact by cranial sensory axons
Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors
Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury
Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor
Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration
Induction of brain-region-specific forms of obesity by agouti
Expression of class-3 semaphorins and their receptors in the neonatal and adult rat retina
NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration
Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix
Lentiviral-mediated transfer of CNTF to schwann cells within reconstructed peripheral nerve grafts enhances adult retinal ganglion cell survival and axonal regeneration
Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo
Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat
Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration
Chemorepellent axon guidance molecules in spinal cord injury
The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease
AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells
Vesicular trafficking of semaphorin 3A is activity-dependent and differs between axons and dendrites
International spinal research trust research strategy. III
Semaphorins in axon regeneration
Gene therapy and transplantation in CNS repair
Overexpression of a truncated TrkB isoform increases the proliferation of neural progenitors
Lentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cord
Proteoglycans as modulators of axon guidance cue function
Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury
Cell-replacement and gene-therapy strategies for Parkinson’s and Alzheimer’s disease
Gene transfer to the spinal cord neural scar with lentiviral vectors
Olfactory ensheathing glia
Human neuroma contains increased levels of semaphorin 3A, which surrounds nerve fibers and reduces neurite extension in vitro
Genetic modification of human sural nerve segments by a lentiviral vector encoding nerve growth factor
Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune “stealth” transgene
Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve
The application of viral vectors to enhance regeneration after peripheral nerve repair
Small Scale Production of Recombinant Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System
Repulsive guidance molecule a (RGMa) induces neuropathological and behavioral changes that closely resemble Parkinson’s disease
Expression of a Mutant SEMA3A Protein with Diminished Signalling Capacity Does Not Alter ALS-Related Motor Decline, or Confer Changes in NMJ Plasticity after BotoxA-Induced Paralysis of Male Gastrocnemic Muscle
Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent
Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface
Gene delivery to neurons of the dorsal root ganglia using adeno-associated viral vectors.
Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.
The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion
Evaluation of Five Tests for Sensitivity to Functional Deficits following Cervical or Thoracic Dorsal Column Transection in the Rat
Overexpression of ATF3 or the combination of ATF3, c-Jun, STAT3 and Smad1 promotes regeneration of the central axon branch of sensory neurons but without synergistic effects
Differential myofiber-type transduction preference of adeno-associated virus serotypes 6 and 9
Gene delivery to rat and human Schwann cells and nerve segments
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer’s disease mouse models
Human Neuroma-in-Continuity Contains Focal Deficits in Myelination
Genetic Deletion of the Transcriptional Repressor NFIL3 Enhances Axon Growth In Vitro but Not Axonal Repair In Vivo
Chondroitinase gene therapy improves upper limb function following cervical contusion injury
Wnt signaling through the Ror receptor in the nervous system
A perspective on the role of class III semaphorin signaling in central nervous system trauma
Spinal cord injury and the neuron-intrinsic regeneration-associated gene program
Early molecular changes in Alzheimer disease
Misdirection and guidance of regenerating axons after experimental nerve injury and repair
A compact dual promoter adeno-associated viral vector for efficient delivery of two genes to dorsal root ganglion neurons
Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa
AAV vector-mediated secretion of chondroitinase provides a sensitive tracer for axonal arborisations
Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A
Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve
Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury
Understanding the neural repair-promoting properties of olfactory ensheathing cells
Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury
A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF
ALS as a distal axonopathy
A Role for Neuropilins in the Interaction between Schwann Cells and Meningeal Cells
Cells in human post-mortem brain tissue slices remain alive for several weeks in culture
Colocalization of high affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer’s disease
Life after death?
P75 neurotrophin receptor in the nucleus basalis of Meynert in relation to age, sex and Alzheimer’s disease
A meta-analysis of microarray-based gene expression studies of olfactory bulb-derived olfactory ensheating cells.
The eighteenth C.U. Ariens Kappers lecture: an introduction.
Immunohistochemical, ultrastructural and functional analysis of axonal regeneration through peripheral nerve grafts containing Schwann cells expressing BDNF, CNTF or NT3.
Intensity-based analysis of dual-color gene expression data as an alternative to ratio-based analysis to enhance reproducibility.
Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection.
Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages.
The chemorepulsive axon guidance protein semaphorin 3A is a constituent of perineuronal nets in the adult rodent brain.
In vivo targeting of subventricular zone astrocytes.
Corticospinal tract transduction: a comparison of seven adeno-associated viral vector serotypes and non-integrating lentiviral vector.
Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors.
The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain.
Analysis of gene expression in Parkinson’s disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death.
Alteration of the microRNA network during the progression of Alzheimer’s disease.
Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling.
Early regenerative effects of NGF-transduced Schwann cells in peripheral nerve repair.
From microsurgery to nanosurgery: how viral vectors may help repair the peripheral nerve.
LLM3D: a log-linear modeling-based method to predict functional gene regulatory interactions from genome-wide expression data.
GFAP-driven GFP expression in activated mouse Muller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors.
Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting in injured corticospinal axons.
The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheating cells in vitro.
early passage bone marrow stromal cells express genes involved in nervous system development supporting their relevance for neural repair.
Comparative gene expression profiling of olfactory ensheating glia and Schwann cells indicates distinct tissue repair characteristics of olfactory ensheating glia.
Chondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury.
A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator.
Lentiviral vector-mediated gradients of GDNF in the injured peripheral nerve: effects on nerve coil formation.
Comparison of AAV serotypes for gene delivery to dorsal root ganglion neurons.
Non-invasive bioluminescence imaging of olfactory ensheating glia and Schwann cells following transplantation into the lesioned rat spinal cord.
NFIL3 and cAMP response element-binding protein form a transcriptional feedforward loop that controls neuronal regeneration-associated gene expression.
Reply: Quantitative evaluation of the human subventricular zone.
Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.
Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior.
Gene therapy approaches to enhance regeneration of the injured peripheral nerve.
Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodents brains.
A novel peptidomics approach to detect markers in cerebrospinal fluid of Alzheimer’s disease samples.
A spatio-temporal analysis of motoneuron survival, axonal regeneration and neurotrophic factor expression after lumbal ventral root avulsion and implantation.
Olfactory ensheating glia and Schwann cells exhibit a distinct interaction behavior with meningeal cells.
A gene network perspective on axonal regeneration.
Modeling early Parkinson’s disease pathology with chronic low dose MPTP treatment.
Genome-wide gene expression and promotor binding analysis identifies NFIL3 as a repressor of C/EBP target genes in neuronal outgrowth.
Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer’s disease.
Homodimerization of the Wnt receptor derailed recruits the Src family kinase SRC64B.
Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer’s disease mouse model.
A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheating cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons.
Negative impact of rAAV2 mediated expression of SOCS3 on the regeneration of adult retinal ganglion cell axons.
Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system.
Neororegeneratieve effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots
Gene therapy for the peripheral nervous system: a strategy to repair the injured nerve.
Use of GFP to analyze morphology, connectivity, and function of cells in the central nervous system.
Nerve surgery and gene therapy: a neurobiological and clinical perspective.
Receptor complexes for each of the class 3 semaphorins.
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Maak kennis met de Verhaagen Groep
Anouck Bahnerth
Student
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Betul Balli
Student
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Bas Blits
Postdoc
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Tzouliano Bracho
Student
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Daniela Carulli
Postdoc
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Luuk de de Vries
PhD student
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Myrthe Griffioen
Staff
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Liza Hemsworth
Student
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Joelle van den herik
staff
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Barbara Hobo
Technician
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Nina van Kesteren
Student
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Julia Leek
Student
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Paul Nijhuis
PhD student
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Kimberly Pietersz
Postdoc
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Naomi Rijk
PhD student
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Maurits Romijn
technician
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Iwin Van de Van de Kamp
Postdoc
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Secil Uyaniker
PhD student
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Michiel Vellema
Staff
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Joost Verhaagen
Department head
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Fred de Winter
Postdoc
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Noa van van Zetten
Student
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Giselle van Zon
Student
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Thuur Zuidweg
Student
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