PhD student position in neuron-glia imaging

PhD student position in neuron-glia imaging to investigate the mechanisms of myelin pathology.
4 jaar


In a multidisciplinary collaboration with the Institute for Chemical Immunology (Leiden University) the axonal signaling group at the NIN has an exciting opportunity for a PhD student position in neuron-glia imaging to investigate the mechanisms of myelin pathology

Project description

One of the hallmarks of multiple sclerosis (MS) is the degradation of the myelin sheath, a complex and poorly understood process which is driven by diverse cell types including neurons, glia and immune cells. Microglia are immune cells that form the first line of defense and involved in both the degradation of the myelin sheath but also recovery and are currently an emerging cell type in the field of neuroscience. A deeper understanding of MS lesions requires to visualize these processes live and longitudinally and examine the basic interactions between neurons and glia. Using a state-of-the-art microscopy infrastructure, you will develop and apply the next generation of activity-based chemical probes to study inflammatory brain lesion in preclinical models of MS.

We expect from you:

You are a highly motivated, self-driven candidate. You have an MSc degree (or equivalent) in neuroscience, glia physiology or another relevant discipline (e.g. immunology) and with a strong interest and neuron-glia interactions. You further possess a demonstrated high level of written and spoken English and possess excellent communication skills, creativity and flexibility. An ideal candidate is a team worker. Additional advantages would be to possess practical experience working with awake behaving animals.

You should expect from us:

  • Mentoring, supervision and training
  • Access to state-of-the art infrastructure
  • Stimulating and multiple international research environments


The project is located in the Axonal Signaling group Prof. dr. Maarten Kole. The Netherlands Institute for Neuroscience is the country’s leading fundamental neuroscience research institute, in the international and progressive city of Amsterdam. The institute provides a critical mass of scientists (spanning more than 27 nationalities) and neuroscience facilities, in a highly interactive, dynamic, multi-cultural environment, with English as the working language. Furthermore, you will work in close interaction with both the Neuroimmunology group headed by Prof. dr. Inge Huitinga and the Department of Molecular Physiology of Prof. dr. Mario van der Stelt (Leiden Institute of Chemistry at Leiden University).


We offer an exciting job at an excellent research institute within a project integrating multiple research environments. The position comes with an attractive package of fringe benefits and is for a period of 4 years in total for a PhD student. The first appointment is for one year with the option for an extension for the remaining period pending on an evaluation.


The salary will be commensurate with experience and institutional guidelines based on the Collective Labour Agreement for Dutch Universities; CAO NU). Full-time monthly salary for a PhD student is € 2.395 in the 1st year to € 3.061 in the 4th year before taxes. In addition, an 8% holiday allowance and an 8.3% year-end bonus are provided. We offer travel expenses, paid parental leave, flexible working hours, 30 days paid leave per year and assistance in finding an accommodation.

Starting date

The position is available from September 2020, but the starting date can be later.

To apply

Please send your application to including:
1. A curriculum vitae
2. An application letter
3. Two reference letters

Evaluation of candidates will begin immediately and continues until the position is filled. We aim to fill the position in the fall of 2020.
All qualified applicants will receive consideration for employment without regard to race, religion, sexual orientation, nationality, disability, etc.

Any acquisition further to this advertisement will not be appreciated.