Steun ons werk
Decorative header background

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

Onderzoeksgroep Van Someren
Publicatiejaar 2020
Gepubliceerd in Journal of Sleep Research
Auteur(s) Yishul Wei, Jeanne Leerssen, Rick Wassing, D. Stoffers, Joy Perrier, Eus Van Someren

Research into insomnia disorder has pointed to large-scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between-network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve-minute resting-state functional magnetic resonance images and T1-weighed images were acquired in 65 people diagnosed with insomnia disorder (21-69 years, 48 female) and 65 matched controls without sleep complaints (22-70 years, 42 female). Pairwise correlations between the activity time series of 14 resting-state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between-network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive-control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.

Steun ons werk

De Stichting Vrienden van het Herseninstituut ondersteunt baanbrekend hersenonderzoek. U kunt ons daarbij helpen.

Steun ons werk