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Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation

Onderzoeksgroep De Zeeuw
Publicatiejaar 2019
Gepubliceerd in Nature Communications
Auteur(s) Julie Marie Lefort, Jean Vincent, Lucille Tallot, Frédéric Jarlier, C.I. De Zeeuw, Laure Rondi-Reig, Christelle Rochefort

Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2B-dependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation.

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