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Stage: developing therapeutics for the treatment of multiple sclerosis

Groep
Type
Internship
Type
Stage
Locatie
Amsterdam
Omschrijving
The Axonal Signaling group has an exciting opportunity for an MSc student internship to characterize and develop a neuropharmacological therapeutical approach in a demyelination mouse model.
FTE
Fulltime
Periode
6-8 maanden
Dagelijkse begeleiding
Mohit Dubey


Omschrijving

The Axonal Signaling group has an exciting opportunity for an MSc student internship in the framework of a project supported by the national multiple sclerosis society. The aim is to characterize and develop a neuropharmacological therapeutical approach in a demyelination mouse model.

Project Description

In this project you will investigate the efficacy of a novel pharmacological compound as a treatment strategy to potentially rescue synaptic, neuronal and behavioral deficits in a demyelinating mouse model. The study involves stereotactic surgery in mice, chronic pharmacological treatment, combined with behavioral, electrophysiological, and serum samples measurements taken to estimate the disease progression. You will learn and have excellent guidance in performing behavioral experiments and electrophysiological (EEG) recordings in freely-moving mice. You will perform drug administration, serum sample collection, immunofluorescent staining of brain slices and confocal microscope imaging. You will be involved in relevant background literature, attend lab meetings and contribute to formulating dosing strategy, data collection, data analysis and research presentation.

Requirements

We are looking for an experienced and highly motivated MSc students familiar with current concepts in neuropharmacology and pharmacokinetics. Ideal candidates have a major interest in neuroimmunology and/or pharmacology and experience with mice handling. This project requires full-time availability for at least 6-8 months.