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Architecture of spatial circuits in the hippocampal region

Publicatiejaar 2014
Gepubliceerd in Philosophical Transactions of the Royal Society B: Biological Sciences
Auteur(s) Cathrin Canto ,
De volgorde van auteurs kan afwijken van de originele publicatie door een tijdelijk technisch probleem.

The hippocampal region contains several principal neuron types, some of which show distinct spatial firing patterns. The region is also known for its diversity in neural circuits and many have attempted to causally relate network architecture within and between these unique circuits to functional outcome. Still, much is unknown about the mechanisms or network properties by which the functionally specific spatial firing profiles of neurons are generated, let alone how they are integrated into a coherently functioning meta-network. In this review, we explore the architecture of local networks and address how they may interact within the context of an overarching space circuit, aiming to provide directions for future successful explorations.

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