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Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular Degeneration

Publicatiejaar 2006
Gepubliceerd in JAMA - Journal of the American Medical Association
Auteur(s) D.D.G. Despriet, C.C.W. Klaver, J.C.M. Witteman, A.A.B. Bergen, I. Kardys, M.P.M. de Maat, S.S. Boekhoorn, J.R. Vingerling, A. Hofman, B.A. Oostra, A.G. Uitterlinden, Th. Stijnen, C.M. van Duijn, P.T.V.M. de Jong

Context: The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) is growing. Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD.
Objectives: To assess the associations between the CFH gene and AMD in the general population and to investigate the modifying effect of smoking, serum inflammatory markers, and genetic variation of C-reactive protein (CRP).
Design, Setting, and Participants: Population-based, prospective cohort study of individuals aged 55 years or older (enrollment between March 20, 1990, and July 31, 1993, and 3 follow-up examinations that were performed between September 1, 1993, and December 31, 2004) in Rotterdam, the Netherlands. The CFH Y402H polymorphism was determined in a total of 5681 individuals. Information on smoking, erythrocyte sedimentation rate, CRP serum levels, and haplotypes of the CRP gene were assessed at baseline.
Main Outcome Measures: All severity stages of prevalent and incident AMD, graded according to the international classification and grading system for AMD.

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