Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coil

Microglial activation after systemic infection has been suggested to
mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live bacteria and lipopolysaccharide (LPS). Here, we describe a mouse model of microglial activation after systemic challenge with live Escherichia coli (E. coli) and compare results with systemic challenge with LPS.