Steun ons werk
Decorative header background

Cerebellar plasticity and associative memories are controlled by perineuronal nets

Onderzoeksgroep De Zeeuw
Publicatiejaar 2020
Gepubliceerd in Proceedings of the National Academy of Sciences of the United States of America
Auteur(s) Daniela Carulli, Robin Broersen, Fred De Winter, Elizabeth M Muir, Maja Mešković, Matthijs de Waal, Sharon I de Vries, Henk-Jan Boele, Cathrin Canto, C.I. De Zeeuw, J. Verhaagen

Perineuronal nets (PNNs) are assemblies of extracellular matrix molecules, which surround the cell body and dendrites of many types of neuron and regulate neural plasticity. PNNs are prominently expressed around neurons of the deep cerebellar nuclei (DCN), but their role in adult cerebellar plasticity and behavior is far from clear. Here we show that PNNs in the mouse DCN are diminished during eyeblink conditioning (EBC), a form of associative motor learning that depends on DCN plasticity. When memories are fully acquired, PNNs are restored. Enzymatic digestion of PNNs in the DCN improves EBC learning, but intact PNNs are necessary for memory retention. At the structural level, PNN removal induces significant synaptic rearrangements in vivo, resulting in increased inhibition of DCN baseline activity in awake behaving mice. Together, these results demonstrate that PNNs are critical players in the regulation of cerebellar circuitry and function.

Steun ons werk

De Stichting Vrienden van het Herseninstituut ondersteunt baanbrekend hersenonderzoek. U kunt ons daarbij helpen.

Steun ons werk