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Distinct feedback actions of behavioural arousal to the master circadian clock in nocturnal and diurnal mammals

Onderzoeksgroep Kalsbeek
Publicatiejaar 2021
Gepubliceerd in Neuroscience and Biobehavioral Reviews
Auteur(s) Pawan Kumar Jha, Hanan Bouâouda, A. Kalsbeek, E. Challet

The master clock in the suprachiasmatic nucleus (SCN) of the hypothalamus provides a temporal pattern of sleep and wake that – like many other behavioural and physiological rhythms – is oppositely phased in nocturnal and diurnal animals. The SCN primarily uses environmental light, perceived through the retina, to synchronize its endogenous circadian rhythms with the exact 24 h light/dark cycle of the outside world. The light responsiveness of the SCN is maximal during the night in both nocturnal and diurnal species. Behavioural arousal during the resting period not only perturbs sleep homeostasis, but also acts as a potent non-photic synchronizing cue. The feedback action of arousal on the SCN is mediated by processes involving several brain nuclei and neurotransmitters, which ultimately change the molecular function of SCN pacemaker cells. Arousing stimuli during the sleeping period differentially affect the circadian system of nocturnal and diurnal species, as evidenced by the different circadian windows of sensitivity to behavioural arousal. In addition, arousing stimuli reduce and increase light resetting in nocturnal and diurnal species, respectively. It is important to address further the question of circadian impairments associated with shift work and trans-meridian travel not only in the standard nocturnal laboratory animals, but also in diurnal animal models.

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