De Zeeuw Groep
Kleine hersenen: Coördinatie & Cognitie
Over de De Zeeuw Groep
Een van de belangrijkste uitdagingen in de neurowetenschappen is om te ontrafelen hoe het geheugen werkt. De groep van Chris de Zeeuw probeert dit centrale thema te onderzoeken door de signalen van de kleine en de grote hersenen te bestuderen tijdens het aanleren van bewegingen.
Aanvankelijk dachten onderzoekers dat de kleine hersenen (het cerebellum) alleen maar betrokken waren bij onze motoriek, maar ze doen veel meer: ze sturen ook de grote hersenen aan. Dat betekent dat de oorzaak – én de oplossing – van bepaalde aandoeningen niet alleen in de grote, maar ook in de kleine hersenen kan liggen. Zo weten we inmiddels dat epileptische aanvallen kunnen worden gestopt door de kleine hersenen op specifieke plaatsen elektrisch te stimuleren.
In de podcast Master the Mind vertelt Chris de Zeeuw meer over het onderzoek van zijn team naar de kleine hersenen. Luister je mee?
Chris de Zeeuw:
‘Het belangrijkste in mijn recente onderzoek is de ontdekking hoe de kleine hersenen ervoor zorgen dat in de grote hersenen de juiste beslissingen worden genomen,’ zegt De Zeeuw. Goed functionerende kleine hersenen doen dat door op de juiste momenten de activiteit van verschillende onderdelen van de grote hersenen te versterken of te verzwakken. Daarbij speelt hoogstwaarschijnlijk de olijf een sleutelrol.
De olijf in de hersenstam is gemaakt uit hersencellen die goed kunnen detecteren of een gebeurtenis verwacht of onverwacht is. Op basis hiervan bepaalt hij op welke momenten de kleine hersenen een beetje harder of juist een beetje zachter moeten vuren, legt De Zeeuw uit. ‘Deze afwisseling zorgt ervoor dat de cellen die onder invloed staan van de kleine hersenen, zoals bepaalde cellen in de hersenstam of de grote hersenen, op het juiste moment worden afgeremd of geactiveerd. Dat is belangrijk om nieuwe dingen aan te leren, zodat we in de toekomst beter kunnen omgaan met onverwachte situaties.’
De kleine hersenen zorgen dus voor de finetuning van de grote hersenen, maar slagen daar minder goed in als er iets mis met ze is. De Zeeuw: ‘Zo kunnen aangedane kleine hersenen aan de basis liggen van aandoeningen zoals epilepsie en autisme, waarbij in de grote hersenen te veel cellen tegelijk respectievelijk te actief zijn of juist te veel worden geremd.’ Bij epilepsie heeft dat ‘kortsluiting’ in de hersenen tot gevolg en treden aanvallen op. Bij autisme is sprake van cognitieve inflexibiliteit – iets wat zich uit in repetitief gedrag – en een verstoorde sociale communicatie, blijkt uit De Zeeuws onderzoek bij muizen. Muizen bij wie met autisme geassocieerde genen opzettelijk waren veranderd, vertoonden deze twee vormen van typisch autistisch gedrag.
‘Het behandelen van autisme is op dit moment nog lastig omdat het probleem al vroeg in de ontwikkeling optreedt,’ zegt De Zeeuw. Epilepsie behandelen gaat beter. ‘Wanneer medicijnen niet meer helpen, kunnen epileptische aanvallen worden gestopt door de kernen van de kleine hersenen te stimuleren,’ zegt hij op basis van onderzoek bij epileptische muizen. ‘Bij deze muizen hebben we elektroden in de kleine hersenen ingebracht. Daardoor weten we waar we ze bij patiënten moeten plaatsen, en wanneer en hoe sterk we ze moeten stimuleren om een epileptische aanval te stoppen.’ De resultaten van het muizenonderzoek zijn zo overtuigend, dat deze operatie nu ook experimenteel wordt gedaan bij enkele kinderen met ernstige epilepsie tussen de 6 en 14 jaar bij wie medicatie niet helpt.
Omdat een operatie heel belastend is, wordt nu ook onderzocht of het mogelijk is om epileptische aanvallen te stoppen met ultrasound. Daarbij wordt geluid gebruikt om hersenactiviteit te meten en te beïnvloeden. De Zeeuw: ‘Dat is echt een doorbraak. Het lukt nu al bij kleine kinderen door de fontanel heen, en we hebben een technische proof of principle dat we ook door de schedel heen kunnen meten en stimuleren. De komende jaren gaan we daar verder mee aan de slag. Het zou geweldig zijn als dat gaat lukken, want dat biedt ook weer extra mogelijkheden om autisme en de behandeling daarvan te onderzoeken.’
Publicaties
Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex
Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning
Keeping track of time
Purkinje cell models
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model
Plasticity mechanisms of genetically distinct Purkinje cells
Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning
Patient-Specific Vascular Flow Phantom for MRI- and Doppler Ultrasound Imaging
Impact of enriched environment on motor performance and learning in mice
A role for the cerebellum in motor-triggered alleviation of anxiety
Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia
Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice
Disynaptic inhibitory cerebellar control over caudal medial accessory olive
Four-dimensional computational ultrasound imaging of brain hemodynamics
The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme
Accessible and reliable neurometric testing in humans using a smartphone platform
Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling
Swept-3D Ultrasound Imaging of the Mouse Brain Using a Continuously Moving 1D-Array Part II
Heterogeneous encoding of temporal stimuli in the cerebellar cortex
Whisker kinematics in the cerebellum
Synaptic mechanisms for associative learning in the cerebellar nuclei.
Human brain mapping using co-registered fUS, fMRI and ESM during awake brain surgeries
A common cause for nystagmus in different congenital stationary night blindness mouse models
Swept-3D Ultrasound Imaging of the Mouse Brain Using a Continuously Moving 1D-Array Part I
Cerebellar nuclei
How inhibitory and excitatory inputs gate output of the inferior olive
Purkinje cell microzones mediate distinct kinematics of a single movement
Case report
cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning
The integrated brain network that controls respiration
Myopia control in Mendelian forms of myopia
Functional imaging of the exposed brain
#2 A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals
A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals
Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity
Cerebellum-dependent associative learning is not impaired in a mouse model of neurofibromatosis type 1
High-resolution micro-Doppler imaging during neurosurgical resection of an arteriovenous malformation
cATR Tracing Approach to Identify Individual Intermediary Neurons Based on Their Input and Output
#1 Interpreting thoughts during sleep
Interpreting thoughts during sleep
Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz
Biallelic PAX5 mutations cause hypogammaglobulinemia, sensorimotor deficits, and autism spectrum disorder
Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques
Time and tide of cerebellar synchrony
Controlling absence seizures from the cerebellar nuclei via activation of the Gq signaling pathway
The Role of GJD2(Cx36) in Refractive Error Development
Stimulus generalization in mice during Pavlovian eyeblink conditioning
Olivocerebellar control of movement symmetry
Purkinje cells translate subjective salience into readiness to act and choice performance
Input and output organization of the mesodiencephalic junction for cerebro-cerebellar communication.
Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease
Activity of Cerebellar Nuclei Neurons Correlates with ZebrinII Identity of Their Purkinje Cell Afferents
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
NMDARs in granule cells contribute to parallel fiber-Purkinje cell synaptic plasticity and motor learning
OptiFlex
Single-pulse stimulation of cerebellar nuclei stops epileptic thalamic activity
Protein phosphatase 2B dual function facilitates synaptic integrity and motor learning
How to Identify Responders and Nonresponders to Dorsal Root Ganglion-Stimulation Aimed at Eliciting Motor Responses in Chronic Spinal Cord Injury
Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1
Sleep quality does not mediate the negative effects of chronodisruption on body composition and metabolic syndrome in healthcare workers in Ecuador
Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus
Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior
Pavlovian eyeblink conditioning is severely impaired in tottering mice
Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts
Diversity and dynamism in the cerebellum.
WhiskEras
A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior
Unilateral L2-Level DRG-stimulation Evokes Bilateral CPG-Like Motor Response in a Patient with Chronic Pain
How the COVID-19 pandemic highlights the necessity of animal research
Blood Pressure in Andean Adults Living Permanently at Different Altitudes
Decoding the infrastructure of the cerebellum
The human cerebellum has almost 80% of the surface area of the neocortex.
The Dorsal Root Ganglion as a Novel Neuromodulatory Target to Evoke Strong and Reproducible Motor Responses in Chronic Motor Complete Spinal Cord Injury
Translation information processing is regulated by protein kinase C-dependent mechanism in Purkinje cells in murine posterior vermis
Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum
Cerebellum
Genetic risk for Alzheimer disease in children
Bilateral L2 dorsal root ganglion-stimulation suppresses lower limb spasticity following chronic motor complete Spinal Cord Injury
AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation
Cerebellar plasticity and associative memories are controlled by perineuronal nets
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy
Single subject and group whole-brain fMRI mapping of male genital sensation at 7 Tesla
Functional Ultrasound (fUS) During Awake Brain Surgery
Sleep deprivation directly following eyeblink-conditioning impairs memory consolidation
NINscope, a versatile miniscope for multi-region circuit investigations
Synthetic Polymers Provide a Robust Substrate for Functional Neuron Culture
SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces
Differential Coding Strategies in Glutamatergic and Gabaergic Neurons in the Medial Cerebellar Nucleus
Action perception recruits the cerebellum and is impaired in patients with spinocerebellar ataxia
Whole brain 7T-fMRI during pelvic floor muscle contraction in male subjects
TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells
Glissades Are Altered by Lesions to the Oculomotor Vermis but Not by Saccadic Adaptation
Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells
Response to “Fallacies of Mice Experiments”
Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation
Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation
Quasiperiodic rhythms of the inferior olive
Variability and directionality of inferior olive neuron dendrites revealed by detailed 3D characterization of an extensive morphological library
Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System
Neurons of the inferior olive respond to broad classes of sensory input while subject to homeostatic control
Music affects rodents: a systematic review of experimental research.
Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity
Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype
A cortico-cerebellar loop for motor planning.
Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.
Intrinsic excitement in cerebellar nuclei neurons during learning
Early Trajectory Prediction in Elite Athletes
Clinical, electrophysiological, and cutaneous innervation changes in patients with bortezomib-induced peripheral neuropathy reveal insight into mechanisms of neuropathic pain
Differential effects of Foxp2 disruption in distinct motor circuits
The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer
Cerebellar learning properties are modulated by the CRF receptor in granular cells
Differentiating Cerebellar Impact on Thalamic Nuclei
Chloride Homeostasis in Neurons With Special Emphasis on the Olivocerebellar System: Differential Roles for Transporters and Channels
Cerebellar transcranial direct current stimulation interacts with BDNF Val66Met in motor learning
Conditioned climbing fiber responses in cerebellar cortex and nuclei
Impact of NMDA Receptor Overexpression on Cerebellar Purkinje Cell Activity and Motor Learning
Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia
A cerebellar mechanism for learning prior distributions of time intervals
Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII
Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice
Synchronicity and Rhythmicity of Purkinje Cell Firing during Generalized Spike-and-Wave Discharges in a Natural Mouse Model of Absence Epilepsy
PRRT2-dependent dyskinesia
Ablation of TFR1 in Purkinje cells inhibits mGlu1 trafficking and impairs motor coordination, but not autistic-like behaviors
Caffeine has no effect on eyeblink conditioning in mice
Impairment of Long-Term Plasticity of Cerebellar Purkinje Cells Eliminates the Effect of Anodal Direct Current Stimulation on Vestibulo-Ocular Reflex Habituation
The reduction of intraepidermal P2X3 nerve fiber density correlates with behavioral hyperalgesia in a rat model of nerve injury-induced pain
An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum
BrainFrame
Cerebellar perineuronal nets in cocaine-induced pavlovian memory: Site matters
Serial, parallel and hierarchical decision making in primates
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Mechanisms underlying vestibulo-cerebellar motor learning in mice depend on movement direction
Cerebellar Granule Cells: Dense, Rich and Evolving Representations
Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder
Performance in eyeblink conditioning is age and sex dependent
Modulation of 7 T fMRI Signal in the Cerebellar Cortex and Nuclei During Acquisition, Extinction, and Reacquisition of Conditioned Eyeblink Responses
The Sleeping Cerebellum
Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning
Hepatitis E virus infects neurons and brains
Enhancing Heart-Beat-Based Security for mHealth Applications
Cerebellar function and ischemic brain lesions in migraine patients from the general population
Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3
Whole-Cell Properties of Cerebellar Nuclei Neurons In Vivo
Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.
Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
Impaired Spatio-Temporal Predictive Motor Timing Associated with Spinocerebellar Ataxia Type 6
A 1-night operant learning task without food-restriction differentiates among mouse strains in an automated home-cage environment
SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination.
The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper
Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning
Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo
Synaptic vesicle dynamic changes in a model of fragile X
Evolving Models of Pavlovian Conditioning
Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination
Controlling Cerebellar Output to Treat Refractory Epilepsy
Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels
The light spot test
Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model
Within-strain variation in behavior differs consistently between common inbred strains of mice
Cerebellar control of gait and interlimb coordination
In Vivo Differences in Inputs and Spiking Between Neurons in Lobules VI/VII of Neocerebellum and Lobule X of Archaeocerebellum
Forward Signaling by Unipolar Brush Cells in the Mouse Cerebellum
The Formation of Hierarchical Decisions in the Visual Cortex
The anatomy of fear learning in the cerebellum
Editorial on the Honorary Cerebellum Issue for the Retirement of Enrico Mugnaini
Motor Learning and the Cerebellum
Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS
Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function
Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice
Cerebellar output controls generalized spike-and-wave discharge occurrence
Spinocerebellar Ataxia Type 6 Protein Aggregates Cause Deficits in Motor Learning and Cerebellar Plasticity
High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons
Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control
Regional functionality of the cerebellum
Hippocampal-cerebellar interaction during spatio-temporal prediction
Enhanced AMPA receptor function promotes cerebellar long-term depression rather than potentiation
High bandwidth synaptic communication and frequency tracking in human neocortex
Peak misdetection in heart-beat-based security
Cerebellar Cortex and Cerebellar Nuclei Are Concomitantly Activated during Eyeblink Conditioning
Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia
Cerebellar potentiation and learning a whisker-based object localization task with a time response window
Distinct roles of α- and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells
Familial Alzheimer’s disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis
A role for Bicaudal-D2 in radial cerebellar granule cell migration
Modulation of electrotonic coupling in the inferior olive by inhibitory and excitatory inputs
Motor systems
Sheltering behavior and locomotor activity in 11 genetically diverse common inbred mouse strains using home-cage monitoring
Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action
Variable timing of synaptic transmission in cerebellar unipolar brush cells
Cerebellar modules operate at different frequencies
A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice
Questioning the cerebellar doctrine
Behavioral correlates of complex spike synchrony in cerebellar microzones
Spinal autofluorescent flavoprotein imaging in a rat model of nerve injury-induced pain and the effect of spinal cord stimulation
Gating of long-term potentiation by nicotinic acetylcholine receptors at the cerebellum input stage.
Reevaluating the role of LTD in cerebellar motor learning.
Properties of the nucleo-olivary pathway: an in vivo whole-cell patch clamp study.
Strength and timing of motor responses mediated by rebound firing in the cerebellar nuclei after Purkinje cell activation.
Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei.
The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice.
Perceptual learning, motor learning, and automaticity.
Role of the cerebellar cortex in conditioned goal-directed behavior.
Cerebellar molecular layer interneurons – computational properties and roles in learning.
Anomalous diffusion imposed by dendritic spines (Commentary on Santamaria et al.).
Long-term changes in cerebellar activation during functional recovery from transient peripheral motor paralysis.
The neural code(s) of the cerebellum.
Encoding of whisker input by cerebellar Purkinje cells.
Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase.
Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity.
T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning.
Distributed synergistic plasticity and cerebellar learning.
Towards mouse models of preservation: a heritable component in extinction of operant behavior in fourteen standard and recombinant inbred mouse lines.
Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning.
Motor learning in children with neurofibromatosis tyoe I.
Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potetiation and cerebellar motor learning.
NR2A subunit of the NMDA receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning.
A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo
Synaptic transmission and plasticity at inputs to murine cerebellar purkinje cells are largely dispensable for standard nonmotor tasks.
Motor deficits in Neurofibromatosis 1 mice: the role of the cerebellum.
Novel candidate genes associated with hippocampal oscillations.
Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model.
Cerebellar ataxia by enhanced CaV2.1 curents is alleviated by Ca2+-dependent K+-channel activators Cacna1aS218L mutant mice.
Independent genetic loci for sensorimotor gating and attentional performance in BXD recombinant inbred strains.
Autofluorescent flavoprotein imaging of spinal nociceptive activity.
Anatomical investigation of potential contacts between climbing fibers and cerebellar golgi cells in the mouse.
Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning.
Purkinje cell-specific ablation of Ca(V)2.1 channels is sufficient to cause cerebellar ataxia in mice.
High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.
Activity and impulsive action are controlled by different genetic and environmental factors.
STD-dependent and independent encoding of input irregularity as spike rate in a computational model of a cerebellar nucleus neuron.
Silencing the majority of cerebellar granule cells uncovers their essential role in motor learning and consolidation.
Causes and consequences of oscillations in the cerebellar cortex.
Spatiotemporal firing patterns in the cerebellum.
Timing in the cerebellum: oscillations and resonance in the granula layer.
Stress, caffeine and ethanol trigger neurological dysfunction through shared mechanisms in a mouse calcium channelopathy.
Impact of aging on long-term ocular reflex adaptation.
betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses.
Long-term effect of prednisolone on functional blink recovery after transient peripheral facial motor paralysis.
Candidate genes in ocular dominance plasticity
fMRI activities in the emotional cerebellum: a preference for negative stimuli and goal-directed behavior.
The cerebellar nuclei take center stage.
Genetic dissection of the function of hindbrain axonal commissures.
Visuomotor cerebellum in human and nonhuman primates.
Effect of simvastatin on cognitive functioning in children with neurofibromatosis Type 1.
Bergmann glial AMPA receptors are required for fine motor coordination.
Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism.
Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
Climbing fiber input shapes reciprocity of Purkinje cell firing.
Timing and plasticity in the cerebellum: focus on the granular layer.
Climbing fiber burst size and olivary sub-threshold oscillations in a network setting.
Diversity and complexity of roles of granule cells in the cerebral cortex.
Anatomical pathways involved in generating and sensing rhythmic whisker movements.
Axonal sprouting and formation of terminals in the adult cerebellum during associative motor learning.
Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar purkinje cells.
Anticipatory grip force control using a cerebellar model.
neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.
High frequency burst firing of granule cells ensures transmission at the parallel fiber to purkinje cell synapse at the cost of temporal coding.
Olivary subthreshold oscillations and burst activity revisited
Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment.
Gerelateerd nieuws
Hoe onze kleine hersenen betrokken zijn bij timing
Kernen in onze kleine hersenen blijken belangrijker dan gedacht
Nieuwe publicatie: Postsynaptic plasticity of Purkinje cells in mice is determined by molecular identity
Nieuw kinderboek: Darya en de denkmachine
Snelle oogbewegingen tijdens slaap laten zien waar muis over droomt
Subsidie voor wetenschappelijk toponderzoek
Niet zomaar een omhulling
Oorzaak aangeboren nystagmus opgehelderd
Maak kennis met de De Zeeuw Groep
Ralph Broer
Student
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Robin Broersen
PhD student
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Cathrin Canto
Postdoc
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Sanne Elhorst
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Nico Flierman
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Cynthia Geelen
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Geoffrey-Alexander Gimenez
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Wouter Kamermans
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Rachel Koops
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Semih Sermet
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Sarah van der Zwaag
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Beerend Winkelman
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Chris de Zeeuw
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